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Balance Inside, Bliss Outside

A Century of Probiotics Pioneering

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Did you know…Saccharomyces boulardii CNCM I-745 was the world's first probiotic drug to hit the market.

Did you know…
Saccharomyces boulardii CNCM I-745 was the world's first probiotic drug to hit the market.

A BREAKTHROUGH HEALTH INNOVATION

From a Life-Changing Discovery to a Gold Standard

In 1923, during an expedition in Southeast Asia, French microbiologist Henri Boulard made a chance discovery. He observed locals drinking a special tea made from the skins of two tropical fruits, litchis and mangosteens, to alleviate stomach problems, including diarrhea. Through his research, Boulard identified a yeast strain, Saccharomyces boulardii CNCM I-745, as the key ingredient behind the tea's remarkable anti-diarrheal properties. 

Years later, in 1953, Saccharomyces boulardii CNCM I-745, also known as Bioflor®, was successfully introduced into commercial use. 

Today, Bioflor® has become the gold standard in diarrhea management1,2 and is widely used in association with antibiotics and on various other occasions, making it the most-sold probiotic drug worldwide. It is suitable for individuals of all ages, from 3 months old and onwards. With its natural origin and 40 years of pharmacovigilance, we prioritize the safety and well-being of our consumers above all.

Our mission is to empower you to take charge of your sustainable health by promoting a balanced gut microbiota. Let’s embark on this journey together today!
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Key Facts and Figures of Success3

No.1 Recommended
in Most International Guidelines

76% Worldwide Coverage

95+ Countries Operated

70+ Years in the Market

130+ Clinical Trials

366 Million
Patients Treated since 1980

Reference:

  1. McFarland, LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World journal of gastroenterology: WJG. 2010; 16(18): 2202.
  2. More MI, and Swidsinski, A. Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis–a review. Clinical and experimental gastroenterology. 2015; 8: 237.
  3. Data on file. Biocodex.